Notorious Sicilian Mafia boss Salvatore “Toto” Riina has died in a prison hospital from cancer, Italian media reports say.
Riina, 87, former boss of the feared Cosa Nostra, was jailed in 1993.
He was serving 26 life sentences and is believed to have ordered more than 150 murders.
Riina had been in a medically-induced coma and his family had been given special permission to visit him in a hospital in Parma.
The mobster’s son, Giovanni, is serving a life sentence in jail, and his other son, Salvo, is confined by law to the city of Padua.
Riina was behind a series of mafia bombings in Rome, Milan and Florence in 1993, which left 10 people dead.
A year earlier, two anti-Mafia judges – Giovanni Falcone and Paolo Borsellino – were killed in Riina’s “war against the state”.