Tupac, who was killed at the age of 25 in 1996, was inducted into the Rock And Roll Hall Of Fame that evening.
Alicia was clearly giving it her all as she sang from behind the piano during her powerful performance.
Snoop, meanwhile, was joined by YG for a performance of Gangsta Party.
And T.I. remembered Tupac by singing his song Keep Ya Head Up, while Treach sang Hail Mary, adds Billboard.